#WHAT IS THE SCID 5 PD TRIAL#

Psychologically traumatic events like terrorist acts, civil wars, community violence, and natural disasters are highly prevalent in people’s lives. Retrospectively registered, 15 March 2019.

#WHAT IS THE SCID 5 PD TRIAL#

Trial registrationĬlinical Trials, NCT03833453. Results will reveal which treatment works best for which individual patient, thereby guiding individual treatment choices and personalizing psychiatry. This is the first study to compare the clinical efficacy and cost-effectiveness of integrated EMDR-DBT and EMDR-only in patients with PTSD and comorbid (sub)clinical BPD, while simultaneously identifying individual predictors and mediators of treatment response. In addition, neurobiological predictors and mediators of treatment outcome, such as hair cortisol, FKBP5 and BDNF protein levels and FKBP5 and BDNF methylation status, are measured through hair and blood samples. MethodĪ randomized controlled trial comparing the clinical efficacy and cost-effectiveness of integrated EMDR-DBT ( n = 63) and EMDR-only (n = 63) in treatment-seeking adult patients with PTSD and comorbid (sub)clinical BPD. The current study will therefore evaluate neurobiological predictors and mediators of the individual response to treatment. Moreover, it is not clear yet what treatment works best for which individual patient. The current study will therefore evaluate the comparative clinical efficacy and cost-effectiveness of EMDR-DBT and EMDR-only in patients with PTSD and comorbid (sub)clinical BPD. Dialectical Behaviour Therapy (DBT) for BPD is well established and although there is some evidence that DBT combined with DBT Prolonged Exposure (DBT + DBT PE) is twice as effective in reducing PTSD symptoms than DBT alone, the comparative efficacy of integrated PTSD-DBT and PTSD-only treatment has not been investigated yet. However, a large subgroup with comorbid BPD does not sufficiently respond to PTSD treatment and is more likely to be excluded or to dropout from treatment.

There is growing motivation among clinicians to offer PTSD treatments – such as Eye Movement Desensitization and Reprocessing (EMDR) - to patients with PTSD and comorbid BPD. Comorbidity between Posttraumatic Stress Disorder (PTSD) and Borderline Personality Disorder (BPD) is high.

What is the scid 5 pd